Regeneration of the Diaphysis of a Long Bone of the Skeleton after the Implantation into its Defect of Osteoplastic Material «Easy-Graft CRYSTAL»

The aim of this work is the microscopic study of the dynamics of the healing of the defect of compact bone tissue after the implantation into its cavity of osteoplastic material «easy-graft CRYSTAL». The experiment was conducted on 24 Wistar rats. In the middle third of the femoral shaft of rats there was reproduced perforated defect in the diameter of 2.5 mm to the medullary canal, which was filled with osteoplastic material «easy-graft CRYSTAL». Fragments of the injured bones were examined on the 15th and 30th day by light microscopy with morphometry and scanning electron microscopy. It was found that the osteoplastic material «easy-graft CRYSTAL» in the area of the compact bone tissue defect shows high biocompatibility, osteoconductive properties and provides stability of the defect volume due to good integration with tissue-specific structures of the regenerate and the absence of reliable signs of resorption throughout the period of the experiment. © 2016 Bull. Georg. Natl. Acad. Sci.